Drug Standards
Cayman Chemical Sarafloxacin-d8 hydrochlorid
An internal standard for the quantification of sarafloxacin by GC- or LC-MS
Apexbio Technology LLC Enoxaparin 50mg
Enoxaparin (CAS 679809-58-6) is a low molecular weight heparin derivative that acts by potentiating the inhibitory activity of antithrombin III leading to the inhibition of coagulation factors such as thrombin (factor IIa) Through this mechanism Enoxaparin demonstrates anticoagulant properties Experimental studies indicate that it confers neuroprotection in rat hippocampus following traumatic brain injury via antioxidative and anti-inflammatory pathways Enoxaparin is widely used in research investigating deep vein thrombosis pulmonary embolism traumatic brain injury and thrombotic complications associated with COVID-19
U.S. Pharmacopeia Norphenylephrine hydrochloride, 4779-94-6, MFCD00012879, 25 mg
Linear Formula: HOC6H4CH(CH2NH2)OH · HCl, Molecular Weight: 189.64, mp: 162-164 °C, Synonym: α-Aminomethyl-3-hydroxybenzyl alcohol hydrochloride, 3,α-Dihydroxyphenethylamine hydrochloride, Norfenefrine hydrochloride.
Medchemexpress LLC Doxazosin | 74191-85-8 | 99.9% | C23H25N5O5 | 1 ML
Doxazosin (UK 33274) is a quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors. It is for research use only and not sold to patients.
- Selectively antagonizes postsynaptic α1-adrenergic receptors
- Functions as a long-lasting inhibitor of α1-adrenoceptors
- Used to treat benign prostatic hyperplasia and lower urinary tract symptoms
- May directly inhibit cholesterol synthesis independently of the LDL receptor
- Shown effectiveness in monotherapy and combined therapy with a beta-blocker in clinical observations
- Exhibits minor and transient adverse reactions in some cases
Medchemexpress LLC Donepezil Hydrochloride | 120011-70-3 | 99.9% | 200 MG
Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC50 of 6.7 nM for AChE activity, demonstrating high selectivity for AChE over BuChE. It also exhibits neuroprotective effects against Aβ42 neurotoxicity. The neuroprotective mechanism involves enhanced phosphorylation of Akt and GSK-3β, and reduced phosphorylation of tau and glycogen synthase. Pharmacokinetic studies showed that Donepezil treatment significantly prevents scopolamine-induced memory impairment in mice.
- Reversible, selective AChE inhibitor
- IC50 of 6.7 nM for AChE activity
- High selectivity for AChE over BuChE
- Exhibits neuroprotective effect on Aβ42 neurotoxicity
- Enhances phosphorylation of Akt and GSK-3β
- Reduces phosphorylation of tau and glycogen synthase
- Significantly prevents scopolamine-induced memory impairment in mice
Medchemexpress LLC Benazepril hydrochloride | 86541-74-4 | MFCD00895734 | 100.0% | C24H29ClN2O5 | 1 G
Benazepril hydrochloride is an orally active angiotensin-converting enzyme (ACE) inhibitor that reduces angiotensin-II production. It inhibits oxidative stress and apoptosis via the PI3K/Akt signaling pathway and improves diabetic nephropathy and decreases proteinuria. It is used in the study of hypertension, heart failure, and diabetic nephropathy.
- Orally active ACE inhibitor
- Reduces angiotensin-II production
- Inhibits oxidative stress and apoptosis
- Improves diabetic nephropathy
- Decreases proteinuria
- White to off-white solid appearance
- For research use only
Apexbio Technology LLC Mesalamine 89-57-6 10mM (in 1mL DMSO)
Mesalamine (89-57-6) is a small-molecule inhibitor targeting the I B kinase (IKK) signaling pathway It is designed to modulate the inflammatory response thereby regulating the NF- B pathway and the expression of pro-inflammatory mediators Mesalamine exerts its biological activity primarily through inhibition of cytokine-mediated activation of the NF- B pathway Based on these pharmacological properties mesalamine holds research potential in studies of inflammatory signaling cascades autoimmune conditions and related inflammatory disorders
Apexbio Technology LLC Salmeterol xinafoate 94749-08-3 10mM (in 1mL DMSO)
Salmeterol xinafoate (CAS 94749-08-3) is a long-acting 2-adrenergic receptor agonist that induces smooth muscle relaxation leading to bronchodilation and vasodilation In vitro studies show that salmeterol reduces retinal M ller cell death by inhibiting IRS-1 (Ser307) phosphorylation implicating -adrenergic signaling in cell survival pathways In vivo experiments demonstrate that salmeterol suppresses pro-inflammatory cytokine production in allergen-stimulated murine models and attenuates inflammatory responses via modulation of dendritic cells Clinically salmeterol has been shown to enhance peak expiratory flow in asthma and is studied in combination therapies for persistent asthma supporting its utility in respiratory and immunological research
Apexbio Technology LLC Glipizide 29094-61-9 500mg
Glipizide (CAS 29094-61-9) is a small molecule that acts by inhibiting ATP-sensitive potassium channels in pancreatic cells leading to membrane depolarization and subsequent stimulation of insulin secretion Additionally it modulates ATP-dependent K channels in GABAergic neurons within the brain Glipizide is widely used in research to investigate pancreatic cell physiology insulin release mechanisms and the role of KATP channels in neuroendocrine regulation
eMolecules 1228182-47-5 | Medchem Express | Fenbendazole-d3 | 1mg | 705861420 | HY-B0413S | 302.37 | C15H13N3O2S
Medchem Express | Aldoxorubicin | 5mg | 446267301 | HY-16261 | 1361644-26-9 | MFCD15146982 | 750.758 | C37H42N4O13
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Selleck Chemical LLC Prasugrel 25mg 150322-43-3 CS-747, LY640315
Prasugrel (CS-747, LY640315) is a thienopyridine ADP receptor (P2Y12) antagonist, used for the reduction of thrombotic cardiovascular events. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Capecitabine S1156-200mg
Capecitabine is a tumor-selective fluoropyrimidine carbamate which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU Capecitabine treatment of HCT-15 cells causes condensation of DNA and induces apoptosis
Selleck Chemical LLC Nocodazole S2775-50mg
Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization also inhibits Abl Abl(E255K) and Abl(T315I) with IC50 of 0 21 M 0 53 M and 0 64 M in cell-free assays respectively Nocodazole induces apoptosis
Medchemexpress LLC Harpagoside | 19210-12-9 | 494.49 | 5 MG
Harpagoside can be obtained from *Harpagophytum procumbens*. It exhibits anti-inflammatory, anti-cancer, and protective activities. Harpagoside inhibits COX-1 and COX-2 activity, suppresses NO production, and inhibits HepG2 cell lipid polysaccharide expression, leading to anti-inflammatory and latent pain effects. It also has a protective and degenerative effect on β-oxidation (Aβ).
- Anti-inflammatory activity.
- Anti-cancer activity.
- Protective activity.
- Inhibitory effect on COX-1 and COX-2.
- Suppresses NO production.
- Inhibits HepG2 cell lipid polysaccharide expression.
- Potential neuroprotective effects against Aβ intoxication in an Alzheimer's disease model.